Newly leaked quotes from Prime Minister Benjamin Netanyahu on March 21, 2025, revealed the reasons behind Shin Bet head Ronen Bar's dismissal, with government ministers voting to end his term. Netanyahu cited Bar's public support for a state commission of inquiry into the October 7 failures and questioned his professional conduct. Bar accused Netanyahu of personal motives, while Justice Minister Yariv Levin defended the dismissal, citing a fundamental misunderstanding of governance.

On March 21, 2025, the Israeli government scheduled a "no-confidence" vote for Attorney General Gali Baharav-Miara for Sunday, March 23, 2025, initiating the process to remove her. Justice Minister Yariv Levin criticized Baharav-Miara, and the opposition vowed to challenge the decision in court.

The State Department commented that the firing of the Shin Bet head is an internal matter.

On March 21 and 22, 2025, the IDF conducted airstrikes on military targets in Palmyra and Tiyas Air Base in central Syria. These strikes, aimed at strategic capabilities, reportedly resulted in injuries to two defense personnel.

On March 21, 2025, the IAF intercepted a Houthi missile that triggered sirens in Jerusalem and surrounding areas. Simultaneously, the IDF struck military bases in Syria.

On March 21, 2025, the IDF killed Osama Tabash, the head of Hamas military intelligence, in southern Gaza. Tabash held numerous senior positions within Hamas.

The Houthis reiterated their threat to target Ben Gurion Airport, stating that attacks will continue until the aggression against Gaza stops. They also claimed responsibility for a ballistic missile attack against Israel. The IDF confirmed airstrikes targeting remaining strategic capabilities.

The IDF resumed military operations in Gaza on March 21, 2025, around 2 a.m., launching numerous airstrikes. These strikes specifically targeted mid-level Hamas commanders and some senior Hamas political officials.

Following the resumption of IDF airstrikes on March 21, 2025, Hamas failed to launch any rockets into Israeli territory for nearly eight hours.

On March 21, 2025, IDF Arabic Spokesman Col. Avichay Adraee sent a message to Gaza residents. He advised them to move further into Gaza, away from the border with Israel, to avoid being attacked as part of the renewed hostilities.

On March 21, 2025, Amos Harel reported that Israel is preparing to occupy Gaza, reinstate military rule, and fully control its people.

The UK, France, and Germany renewed their urgent call for a Gaza ceasefire and increased humanitarian access, expressing their deep concern over the rising number of civilian casualties. They stated being "appalled by the civilian casualties" and requested Israel to restore humanitarian access.

On March 21, 2025, the US told the UN that Hamas is to blame for deaths since Israel resumed Gaza hostilities. The US stated that every Gaza death could have been avoided if Hamas accepted a ceasefire.

On March 21, 2025, Israel's Envoy to the UN Danny Danon stated that Hamas can either negotiate or watch its leadership fall. He stressed that comparisons between Palestinian security prisoners and hostages held by Hamas were fundamentally inaccurate and offensive.

On March 19, 2025, U.S. Middle East Envoy Steve Witkoff stated that the Gaza hostage issue is "cutting through the soul of the country."

On March 21, 2025, a letter signed by approximately 40 former hostages was released, calling for an immediate halt in fighting and criticizing the government's conduct. Following renewed Israeli strikes, over 250 family members of current hostages joined in demanding a ceasefire and return to negotiations, accusing the government of sacrificing the hostages.

On March 21, 2025, Jonathan Polin, the father of Hersh Goldberg-Polin, criticized the Israeli government over failed hostage negotiations in a Facebook post. He also publicly thanked Ronen Bar for his efforts to expand the negotiators’ mandate, highlighting Bar's actions when the government refused to do so.

On March 21, 2025, President Herzog congratulated Wiz CEO Assaf Rappaport on the largest acquisition of an Israeli company, a venture-backed startup, by Google.

On March 20, 2025, Shimon Stein wrote that Israel's conference with Europe's far right exposes Jews to real, unbridled antisemitism. On March 21, 2025, Israeli Minister Amichai Chikli defended the conference invite to far-right European politicians.

On March 20, 2025, Netta Ahituv reported that Israel is more sexist than people think, and men pay the price, too.

On March 21, 2025, protests continued near Prime Minister Netanyahu's residence in Jerusalem. Demonstrators protested the Israeli government and demanded the release of hostages in Gaza.

On March 21, 2025, Yossi Verter wrote that Prime Minister Benjamin Netanyahu is as dangerous to Israel as any foe, including Hamas, Hezbollah, and the Houthis.