On 2025-04-22, Hamas announced that a delegation is traveling to Cairo to discuss "new ideas to achieve a ceasefire" after rejecting an Israeli proposal for a "partial" truce.

On 2025-04-22, the head of UNRWA deplored that the famine in the Gaza Strip is "worsening, deliberately," and denounced the consequences of the Israeli blockade, which has suspended humanitarian aid entry into the Palestinian territory since March 2nd, for fifty days.

On 2025-04-22, Israeli strikes in the Gaza Strip resulted in at least 33 deaths, according to Palestinian civil defense and WAFA news agency. The attacks occurred in various locations within Gaza.

On 2025-04-22, two people were killed in Israeli strikes in Lebanon. Jamaa Islamiya confirmed the death of one of its leaders, Hussein Atoui, in an Israeli drone strike that "targeted his car" near Beirut.

On 2025-04-22, Israeli Prime Minister Benjamin Netanyahu is facing accusations from Ronen Bar, the head of Shin Bet, regarding demands of loyalty above the Supreme Court and spying on opponents. Shin Bet chief Ronen Bar accused Prime Minister Benjamin Netanyahu of attempting to fire him for refusing to commit illegal acts to protect Netanyahu's interests, citing events between November 2024 and February 2025. Netanyahu stated he wanted to sack Bar due to a breakdown in trust related to Hamas’s attack in October 2023.

On 2025-04-22, reports detail the aftermath of Pope Francis's death, including a rosary at St. Mary Major Basilica, Vatican funeral preparations, and a statement from Volodymyr Zelenskyy.

On 2025-04-22, activists reported that Sudan's Rapid Support Forces (RSF) killed more than 30 people in a recent attack in Darfur.

On 2025-04-22, gunmen attacked tourists in India-controlled Kashmir, near Pahalgam, resulting in at least 26 deaths, according to Indian police. Prime Minister Narendra Modi condemned the attack, and U.S. President Donald Trump pledged support for India. UN Secretary-General Antonio Guterres also condemned the attack. India’s Minister of Home Affairs Amit Shah headed to Srinagar to review the situation. Mirwaiz Umar Farooq, a key separatist leader in Kashmir, condemned the attack.

On 2025-04-22, Israeli airstrikes in Gaza, including attacks on the Nousseirat refugee camp and Khan Younès, resulted in at least 32 Palestinian deaths. Separately, an Israeli airstrike hit tents sheltering displaced Gazans.

On 2025-04-22, the World Food Programme (WFP) announced it is suspending aid for 650,000 malnourished women and children in Ethiopia starting on 2025-05-01 due to insufficient funding. The WFP also warned that cash and in-kind food assistance for up to one million refugees will stop in June 2025 if additional funding is not received.

On 2025-04-23, it was reported that Tidjane Thiam, president of the Parti démocratique de Côte d’Ivoire (PDCI), has been removed from the electoral list, making him ineligible for the presidential election scheduled for 2025-10-25.

On 2025-04-22, Ukraine summoned the Chinese ambassador to express "grave concerns" about the presence of Chinese fighters in the Russian army and the assistance of Chinese companies to Russia in manufacturing military equipment.

On 2025-04-22, Russian President Vladimir Putin discussed Iran's nuclear program with Oman's Sultan Haitham bin Tariq Al Said in Moscow, focusing on Oman's mediation efforts in US-Iran nuclear talks. A third round of negotiations between Tehran and Washington is scheduled to take place in Oman on Saturday.

On 2025-04-21, US Vice President JD Vance and Indian Prime Minister Narendra Modi held a meeting in New Delhi and spoke positively about US-India trade talks amid tariff threats.

Published on 2025-04-22, an article by Sarah Belouezzane discusses Pope Francis's three years of missteps and errors of judgment regarding the war in Ukraine, dating back to 2025-04-21. The article also mentions that Russia's Easter truce in Ukraine was described as a 'charm offensive' for Trump and France.

On 2025-04-23, Judge Royce Lamberth ordered the reinstatement of USAGM employees and the resumption of funding for certain US government-funded media outlets abroad, including Voice of America (VOA), reversing an earlier attempt by the Trump administration on 2025-04-22.

On 2025-04-22, Ukrainian President Volodymyr Zelenskyy had a private audience with Pope Francis at the Vatican.

On 2025-04-22, representatives of the Jewish community laid flowers at the Jasenovac concentration camp monument to remember the victims of the WWII concentration camp in Croatia.

On 2025-04-21, the US Department of Justice indicted 27 individuals allegedly linked to the Venezuelan gang Tren de Aragua on charges including murder, human trafficking, drug trafficking, and extortion. The US has designated the gang a foreign terrorist organization.

On April 21, 2025, Noor Abdalla, wife of detained pro-Palestinian activist Mahmoud Khalil, reported that Khalil was denied temporary release to attend the birth of their son in New York. An immigration judge in Louisiana had ruled earlier in April that deportation proceedings against Khalil could proceed.

On April 22, 2025, New Zealand First (NZF) party announced proposals to legally define women by biological sex. NZF leader Winston Peters stated the law would “reflect biological reality”. Chris Hipkins, leader of the New Zealand Labour Party, criticized the proposal. The United Kingdom’s highest court also ruled that women are defined by biological sex under the country’s equality laws.