On April 22, 2025, Secretary of State Marco Rubio revealed a significant restructuring of the State Department, involving a 15% reduction in staff within the U.S. and the closure or consolidation of over 100 bureaus globally, aligning with the Trump administration's “America First” policy; the plan includes consolidating 734 bureaus/offices to 602 and transitioning 137 offices to improve efficiency.

On April 22, 2025, Harvard University filed a lawsuit against the Trump administration, alleging attempts to control academic decision-making by threatening to review $9 billion in federal funding after Harvard refused to comply with demands; Harvard seeks to halt a freeze on $2.2 billion in grants.

On April 22, 2025, the IMF warned that Donald Trump’s tariffs have unleashed a “major negative shock” into the world economy, cutting forecasts for US, UK and global growth; the IMF cut its forecast for global GDP growth to 2.8% for this year, 0.5% weaker than its January forecast, with the UK expected to grow by 1.1% (down from 1.6%) and the US by 1.8% (down from 2.7%); Rachel Reeves was due to arrive in the US to advocate for reduced tariffs for the UK, even after Trump's "pause" on reciprocal tariffs, trade barriers remain high; the dollar rose 0.5% after Trump criticized Jay Powell, while Wall Street shares increased following the treasury secretary's suggestion that the trade war with China was unsustainable; the IMF also stated that the probability of a US recession had increased to nearly 40%; U.S. Treasury Secretary Scott Bessent stated the trade war with China is unsustainable, with the US imposing 145% import taxes on China, and China responding with 125% tariffs on U.S. goods.

On April 22, 2025, a judge criticized the Trump administration for acting in 'bad faith' in the deportation case of Kilmar Abrego Garcia, who was mistakenly deported to El Salvador; the judge ordered the administration to provide details about efforts to return him by Wednesday at 6 p.m.

On April 22, 2025, the U.S. federal labor board ruled that Amazon is obligated to collectively bargain with warehouse workers at its San Francisco distribution facility; this follows a complaint by the National Labor Relations Board accusing Amazon of illegally refusing to negotiate with employees after a majority signed union authorization cards in the fall.

On April 22, 2025, Judge Charlotte N. Sweeney extended a temporary order preventing the Trump administration from deporting individuals from Colorado under the Alien Enemies Act of 1798; the order requires 21 days' notice to those targeted for deportation.

On April 22, 2025, three more federal prosecutors resigned, stating they felt pressured into admitting wrongdoing or regret as a condition for being reinstated to their jobs.

On April 22, 2025, Donald Trump announced that he currently has no plans to dismiss Jerome Powell from his position as Federal Reserve Chair.

On April 21, 2025, Donald Trump supported his defense secretary, Pete Hegseth, following reports that Hegseth shared information about US strikes in Yemen in a second Signal group chat that included family; on April 22, 2025, Pete Hegseth blamed ousted Pentagon officials for leaking classified information from a Signal group chat.

On April 22, 2025, Bill Owens, the executive producer of "60 Minutes," resigned; his resignation comes amid a $20-billion lawsuit filed by President Trump against CBS regarding an October interview with then-Vice President Kamala Harris, with Owens citing his inability to make independent decisions due to the lawsuit and pressure from Paramount Global executives.

On April 22, 2025, Treasury Secretary Scott Bessent predicted that extending President Trump’s 2017 tax cuts could pass by July 4, followed by deregulation, at a private JP Morgan investor event.

On April 22, 2025, following Trump's decision to spare Apple from tariffs, other businesses are now seeking similar tariff exemptions.

On April 22, 2025, reports indicated that merchants in Los Angeles are uncertain about the impact of Trump's tariffs and trade wars on the economy, with Ivan Vazquez, owner of Madre Oaxacan Restaurant and Mezcaleria, expressing concerns; tariffs are also expected to increase the cost of raising a child in America, as Elizabeth Mahon, owner of baby store Three Littles in Washington, anticipates tariff-driven price increases; additionally, Trump’s tariffs are affecting rebuilding efforts in fire-ravaged Los Angeles.

On April 22, 2025, Interior Secretary Doug Burgum granted Tyler Hassen, a former oil executive and representative of Elon Musk’s Department of Government Efficiency (DOGE), significant authority to make changes to the Department of Interior, which oversees national parks and over 500 million acres of federal land; conservation groups are concerned about potential firings of park rangers, public land managers, and wildfire specialists.

On April 22, 2025, reports indicated that an increasing number of Southeast Asian immigrants in Southern California are being detained and deported after routine ICE check-ins under the Trump administration; many have lived in the U.S. for years with past criminal convictions and stayed orders.

On April 22, 2025, over 220 higher education leaders signed a joint statement condemning the Trump administration’s efforts to control universities.

On April 21, 2025, House Democrats Robert Garcia and Maxwell Frost visited El Salvador to assist in the return of Kilmar Abrego Garcia to the U.S. after his mistaken deportation; on April 22, 2025, reports surfaced that the Trump administration deported Abrego Garcia to El Salvador despite a court order, claiming he was a member of MS-13 with limited evidence and a doctored image; the administration also contracted with the Salvadoran government to handle "terrorists" but claimed inability to retrieve those mistakenly deported, raising concerns about bypassing due process.

On April 22, 2025, Veronica A. Arteaga criticized U.S. Secretary of Health and Human Services Robert F. Kennedy Jr.'s remarks from the previous week regarding autism, highlighting concerns over potential Medicaid budget cuts that could threaten services for millions of Americans with disabilities; she noted that over 15 million people with disabilities rely on Medicaid nationwide, including more than 1.9 million in California, and that anti-science myths are prevalent at the agency he leads.

On April 22, 2025, during his visit to India, US Vice-President JD Vance described the US-India partnership as crucial for global progress, contrasting India’s potential with a “self-loathing” West; Vance met with India’s Prime Minister Narendra Modi to discuss trade and regional security, invoked Trump’s “drill, baby, drill” slogan to promote US oil and gas exports, and announced the finalization of “terms of reference” for a bilateral trade agreement to help India avoid Trump's tariff increases; the US is currently India’s top trading partner, with both countries aiming to double bilateral trade to $500 billion by 2030.

On April 21, 2025, Department of Homeland Security Secretary Kristi Noem reported that her purse was stolen at a restaurant; the purse contained $3,000 in cash, her passport, license, and apartment keys.