On March 29, 2025, Columbia University's interim President Katrina Armstrong resigned after the university agreed to policy changes demanded by the Trump administration to restore $400 million in government funding. These changes include reviewing admissions policies, banning masks at protests, and increased oversight of the Middle East studies department. Claire Shipman, co-chair of the board, has been appointed as acting president. The Trump administration has also moved to deport several Columbia students involved in pro-Palestinian demonstrations.

On March 27, 2025, Health Secretary Robert F Kennedy Jr announced 20,000 job cuts at the Department of Health and Human Services (HHS). Experts and Democratic politicians warn that these cuts, coupled with cuts from Elon Musk's "department of government efficiency", will lead to a private sector takeover of crucial health services, leaving the US vulnerable to future health emergencies.

On March 29, 2025, in the USA, anti-abortion groups are advocating for the defunding of Planned Parenthood, suggesting that the DOGE should take action.

On March 29, 2025, the New College of Florida fired a Chinese language professor under a state law that restricts Florida’s public universities from hiring individuals they deem to be from “countries of concern”.

On 2025-03-27, a Senate subcommittee questioned the F.A.A. administrator and the U.S. Army’s director of aviation about military aircraft frequently flying too close to commercial airplanes at National Airport, following a fatal collision two months prior.

On March 28, 2025, Donald Trump granted clemency to Carlos Watson, co-founder of Ozy Media, just before Watson was to begin a nearly 10-year prison sentence for fraud. Watson had been ordered to pay $96 million in restitution and forfeiture for deceiving investors. Watson thanked Trump and criticized the sentencing judge.

On March 29, 2025, federal prosecutor Adam Schleifer in Los Angeles was fired at the order of the White House, reportedly citing President Donald J. Trump, following pressure from lawyers representing Andrew Wiederhorn, whom Schleifer was prosecuting for tax evasion. The firing has raised concerns among other prosecutors about free speech and potential political bias in the Justice Department.

On March 29, 2025, a top FDA vaccine official, Dr. Peter Marks, resigned, criticizing Health Secretary Robert F. Kennedy Jr. for promoting misinformation and lies regarding vaccine safety.

On March 29, 2025, the wife of the US defense secretary Pete Hegseth attended two meetings with foreign defense officials during which sensitive information was discussed, according to a new report from the Wall Street Journal.

On March 29, 2025, Pete Hegseth's practice of bringing his brother, Philip Hegseth, on official visits, including to Guantánamo Bay and Asia, has come under scrutiny. Simultaneously, a federal judge has ordered officials, including Pete Hegseth, to preserve all messages in a Signal group chat due to concerns about military strike plans being discussed within it. President Trump considered firing his national security advisor, Michael Waltz, after a Signal chat leak, but signaled his willingness to keep Waltz.

On March 29, 2025, US President Donald Trump said he did not warn car industry executives against raising prices as tariffs on foreign-made autos come into force, telling NBC News he “couldn’t care less” if they do.

On March 29, 2025, White House spokesperson Anna Kelly stated that the US Institute of Peace “has failed to deliver peace” and that Trump “is carrying out his mandate to eliminate bloat and save taxpayer dollars”.

On 2025-03-29, it was reported that Trump ally Kash Patel, now FBI director, claims to have witnessed Trump declassify material taken to Mar-a-Lago, but no evidence supports this claim.

On March 28-29, 2025, most employees at the US Institute of Peace received email notices of their mass firing, the latest step in the Trump administration’s government downsizing led by Elon Musk’s unofficial “department of government efficiency”. The organization, employing about 300 people, is now overseen by Elon Musk’s unofficial “department of government efficiency”.

On March 29, 2025, Musk posted on Twitter/X that he would campaign in Wisconsin this weekend and give away $1m to people who had voted, but later deleted the post. The Wisconsin attorney general, Josh Kaul, also sued Musk and his Pac to stop the giveaway.

On March 29, 2025, people worldwide protested against Elon Musk's attempts to dismantle the US federal government, gathering outside Tesla showrooms. Protest organizers urged people not to buy Tesla products, sell off Tesla stock, and join the “Tesla Takedown” movement.

On March 28, 2025, the Trump administration requested the Supreme Court for permission to resume deportations of Venezuelan migrants to El Salvador under the Alien Enemies Act, after a federal appeals court rejected the government’s petition. A temporary suspension of deportations was imposed by Judge Boasberg, but the government has challenged the order and invoked the "state secrets privilege".

On March 29, 2025, President Trump issued an executive order, citing national security, to remove about one million civil servants across more than a dozen agencies from union representation. The administration also filed a lawsuit in federal court in Texas seeking permission to rescind collective bargaining agreements.

On March 27, 2025, President Trump issued an executive order targeting the Smithsonian Institution, accusing it of promoting a divisive, race-centered ideology. He threatened to cut funding and ordered the restoration of monuments removed due to their association with racist figures, specifically criticizing the exhibit "The Shape of Power" and the National Museum of African American History and Culture.

On March 29, 2025, the Trump administration ordered some French companies with US government contracts to comply with his executive order banning diversity, equity, and inclusion programmes.

On March 28, 2025, U.S. Secretary of Homeland Security, Kristi Noem, stated that Mexico has made progress in security and migration, but there is still much to be done.

On 2025-03-28, Danish Foreign Minister Lars Løkke Rasmussen criticized US President Donald Trump's comments on Denmark and Greenland, while US Vice President JD Vance visited Greenland, urging a change in Denmark's approach and Trump expressed support for Greenland's independence.

On March 29, 2025, UK and EU diplomats urged Prime Minister Keir Starmer to strongly oppose Donald Trump's potential tariffs on British exports, including cars, steel, and aluminum. The Office for Budget Responsibility warned of significant economic consequences.