On April 1, 2025, Democratic Senator Cory Booker of New Jersey concluded a speech on the Senate floor after 25 hours and five minutes. The speech protested what he called a 'grave and urgent' threat to Americans from the White House.

On April 1, 2025, House Speaker Mike Johnson's attempt to block a bipartisan proposal allowing new parents in Congress to vote by proxy failed, with the effort failing 206-222. Nine GOP lawmakers joined Democrats, delaying the House GOP's package of bills.

On April 1, 2025, Lt. Gen. Dan Caine's confirmation hearing to lead the Joint Chiefs of Staff was held, where Democrats expressed concerns about Mr. Trump firing Gen. Charles Q. Brown, while Republicans praised Caine. During the hearing, General Caine addressed Defense Secretary Pete Hegseth's disclosure of U.S. fighter jet attack plans, stated that he views Russia as one of America’s main adversaries, and Senator Mazie Hirono referenced the treatment of Gen. Mark A. Milley by President Trump.

On April 1, 2025, voters in Wisconsin elected Liberal Susan Crawford to the state supreme court, defeating a Musk-backed candidate. This victory allows liberals to maintain a narrow majority and is seen as a test of political clout.

On March 31, 2025, a federal judge ruled that Alabama's attorney general cannot prosecute groups for helping women travel out of state for abortions. The ruling, published on April 1, 2025, prevents Alabama from enforcing its laws outside its boundaries.

On April 1, 2025, reports indicated that the Trump administration acknowledged in court documents an 'administrative error' leading to the deportation of a Maryland man with protected status to El Salvador.

On April 1, 2025, Attorney General Pam Bondi announced that the death penalty would be sought for Luigi Mangione, accused of murdering Brian Thompson in 2024. This aligns with President Trump's executive order to resume death penalty requests in federal cases.

On April 1, 2025, Assistant U.S. Attorney Adam Schleifer was fired shortly after a right-wing influencer resurfaced his old tweets criticizing Trump.

On April 1, 2025, US President Donald Trump announced planned tariffs for Wednesday, calling it a "Day of Liberation," expected to include reciprocal tariffs. Senate Republicans are considering joining Democrats to oppose President Trump's tariffs on Canadian imports, which are set to go into effect on April 2, 2025; Senator Tim Kaine offered a resolution to terminate the emergency order Trump is using to justify the tariffs.

On April 1, 2025, reports indicated that Donald Trump's administration, guided by Elon Musk's 'department of government efficiency,' has significantly cut the National Oceanic and Atmospheric Administration (Noaa), leading to numerous firings and resignations.

On April 1, 2025, Gov. Gavin Newsom stated his belief that it’s unfair for transgender athletes to compete in women’s sports, attributing the unplanned comment to pressure from Charlie Kirk. Critics, including State Sen. Scott Wiener, pointed to Newsom's previous support for a California law allowing trans students to compete based on gender preference, while some Democrats allege Newsom strategically abandoned a vulnerable group after Republicans made the issue a liability.

On April 1, 2025, Republican Randy Fine won a special election for a House seat in Florida, succeeding Mike Waltz. Democrat Josh Weil presented a strong challenge in the deep-red district.

Published on April 1, 2025, Louisiana voters rejected four constitutional amendments proposed by Republican Governor Jeff Landry. The amendments, concerning crime, courts, and finances, were defeated by margins exceeding 60%.

On April 1, 2025, it was reported that Joe Biden issued a moratorium on federal executions but commuted the sentences of 37 out of 40 death row inmates to life imprisonment near the end of his term.

On April 1, 2025, some laid-off federal health employees were mistakenly instructed to contact the deceased director Anita Pinder for discrimination complaints. This reflects the Trump administration's efforts to reduce the federal workforce.

On April 1, 2025, dozens of Institute of Museum and Library Services (IMLS) staff were placed on administrative leave following President Donald Trump's executive order to reduce the agency's size. The American Federation of Government Employees (AFGE) Local 3403 reported the action, which could disrupt programs vital to museums and libraries nationwide.

On April 1, 2025, it was reported that the Save Act, which aims to eliminate rare instances of noncitizen voting by imposing stricter voter ID requirements, is set for a vote. Concerns have been raised about its potential to disenfranchise eligible voters.

On April 1, 2025, Cornell University student Momodou Taal, facing deportation, announced his departure from the U.S. due to a revoked visa following disruptive protests.

On April 1, 2025, nytimes.com reported that immigration officials detained the former Taliban Ambassador to Spain.