On April 3, 2025, President Trump fired six National Security Council officials after a meeting with Laura Loomer. On April 3, 2025, Donald Trump reportedly fired NSA director Gen Tim Haugh, civilian deputy Wendy Noble, and Maggie Dougherty, according to a 2025-04-04 report, leading to denouncement from top congressional Democrats.

As reported on 2025-04-04, Governor Gavin Newsom plans to request exemptions from President Trump's retaliatory tariffs for California's exports. On 2025-04-04, it was reported that President Trump has threatened to freeze $510m in grants to Brown University in Rhode Island following last autumn’s Palestinian solidarity protests.

On April 3, 2025, it was reported that Justice Department officials will allow actor Mel Gibson, a supporter of President Trump, to own guns again. Attorney General Pam Bondi approved the decision, which also applies to nine others.

On April 3, 2025, Dr. Mehmet Oz was confirmed to lead the Centers for Medicare and Medicaid Services in a 53-45 party-line vote.

On April 3, 2025, the Trump administration, via the Education Department, threatened to withhold federal funding from public schools unless state education officials verified the elimination of all programs that it said unfairly promoted diversity, equity and inclusion.

The deadline for TikTok to divest or sell its assets to a non-Chinese owner is looming on 2025-04-05. President Trump said earlier this week he would “like to see TikTok remain alive”.

On April 3, 2025, JD Vance stated that Elon Musk will remain a friend and advisor to the vice-president and Donald Trump after leaving his government role.

As reported on 2025-04-03, Doug Emhoff's law firm reached an agreement with the Trump administration on 2025-04-01.

On 2025-04-02, former Costa Rican President and Nobel Peace Prize laureate Oscar Arias was notified by the U.S. State Department that his U.S. visa had been revoked due to unspecified information that made him ineligible.

On April 3, 2025, Trump's tariff announcement triggered global financial market turmoil, causing trillions in losses and increasing recession fears. The three major US stock funds experienced their worst day since June 2020, with the Nasdaq falling 6%, and the Dow Jones dropping significantly, according to a report published on the same day.

On April 3, 2025, Canadian Prime Minister Mark Carney announced Canada will retaliate against Trump's tariffs with a 25% tax on US vehicles not compliant with the continental free trade deal.

On April 3, 2025, Republican senators began to publicly criticize Trump's tariffs as bad policy in response to the tanking stock markets and international criticism. Four Republican senators openly defied Trump by voting for a Senate resolution from Democrats demanding the reversal of 25% tariffs on Canadian products, with senators Paul, Collins, Murkowski and Tillis expressing concerns.

On April 3, 2025, President Trump proclaimed his new tariffs are "reciprocal," but experts disagree, stating that Trump's imposed rate is much higher than other countries'.

On April 3, 2025, it was reported that the Trump administration's tariffs are based on a novel calculation focusing on America’s trade deficits, not on other countries' tariffs.

On April 2, 2025, President Trump announced a baseline of 10% tariffs on imports into the United States, with higher tariffs on goods from some countries. On 2025-04-03, Trump announced that the U.S. would begin applying a universal baseline tariff of 10% on imported goods from all foreign countries, in addition to existing tariffs.

On 2025-04-03, the National Restaurant Assn. is warning that the tariffs will hit restaurants hard and have requested that food and beverages be exempt.

On 2025-04-02, President Trump announced a new aggressive tariff campaign, prompting mixed reactions. Some companies pledged investments in the U.S.

On April 3, 2025, Commerce Secretary Howard Lutnick stated that Trump's tariffs will pay dividends in the long run, as foreign companies move their factories to the U.S.

On April 3, 2025, it was noted that fifty-eight percent of economists surveyed by the Kent A. Clark Center disagreed with the claim that America’s trade deficit would grow smaller because of the higher tariffs.

On April 3, 2025, Jesse Rothstein, a UC Berkeley economist, stated that Trump’s view of international trade is overly simplistic because it only accounts for material goods and not professional services.

On 2025-04-03, it was reported that China condemned the US's new tariffs on Chinese goods, which will take effect on 2025-04-09. The additional levy takes effect on 9 April, bringing the total tariff to 54%.

On 2025-04-02, Jonathan Reynolds mentioned that business leaders are advising the government to remain calm regarding US tariffs. Badenoch offered to help Labour with US trade talks, stating that Trump's tariffs will make 'all of us poorer', and Keir Starmer stated that Trump's tariffs are the start of a 'new era'.

On 2025-04-03, a coalition of 19 Democratic attorneys general filed a lawsuit against the Trump administration, challenging an executive order seeking to overhaul the nation’s elections, arguing it was “unconstitutional, anti-democratic, and un-American”. The lawsuit, filed in federal court in Massachusetts, challenges proof-of-citizenship requirements for voter registration and new rules for mail ballots.

On April 3, 2025, a federal judge temporarily blocked the Department of Health and Human Services (HHS) from terminating $11 billion in public health funds allocated to states during the Covid-19 pandemic. The lawsuit was filed by a coalition of Democratic states.

On April 3, 2025, senators introduced bipartisan legislation to regain Congressional power over tariffs following Trump's new import taxes.

On 2025-04-03, Kamala Harris criticized President Trump's policies and hinted at a potential run for California governor in 2026, as reported on the same day.

On 2025-04-03, Keisha Lance Bottoms was present at the Leading Women Defined gathering in Dana Point, with speculation of a potential run for governor.

A 2025-04-03 report indicates that Trump's 2025 tariffs are estimated to increase U.S. consumer prices and reduce U.S. economic growth.

On 2025-04-03, Jonathan Reynolds revealed that Trump’s administration had raised objections to the UK’s food safety standards during trade talks. Trump has also targeted the UK’s digital services tax, a 2% levy introduced in 2020 on the revenues of tech companies including Amazon, Google and Apple.